REGISTRATION

PROGRAM

DECEMBER 15-16-17 2022
Florence, ITALY

8:30

Opening Ceremony

(Welcome Greetings)

9:00

PAMM Oral Communications – Session 1

New therapeutics in thoracic malignancies: from bench to bedside

inaugural lecture

9:00-9:30

Major Advances in Metastatic NSCLC: Inactive state KRAS (G12C) inhibitors

Rafael Rosell (Catalan Institute of Oncology, Barcelona, Spain)

9:30-9:45

Improving precision oncology effectiveness in advanced NSCLC by exploiting a co-clinical platform

Paolo Bironzo (Università di Torino, Turin, Italy)

09:45-10:10

Molecular drivers and therapeutic targets of Lineage Plasticity in Lung Cancer

Triparna Sen (Memorial Sloan Kettering, New-York, USA)

10:10-11:10

Free communications from abstracts by PAMM members/collaborators :

4 Selected Abstracts

Chairmen:
Godefridus J. Peters (Amsterdam UMC, VU University, Amsterdam, The Netherlands and Medical University of Gdansk, Poland), Carmelo Tibaldi (Ospedale S. Luca, Lucca, Italy)

11:10

Coffee-Break

11:30

Clinical Symposium 1

– Lung cancer therapeutics

11:30-12:00

Optimizing efficacy of immunotherapy with combinations

Marcello Tiseo (Università di Parma, Parma, Italy)

12:00-12:30

Why and how target KRAS in daily practice today

Fabrice Barlesi (Institut Gustave Roussy, Paris, France)

keynote lecture

12:30-13:00

Use of liquid biopsies to tailor actionable mutations in NSCLC

Christian Rolfo (Tisch Cancer Institute at Mount Sinai, New York, USA)

Chairmen:
Francesco Annunziato (Università di Firenze – AOU Careggi, Florence Italy), Nadia Zaffaroni (Istituto Nazionale Tumori Milano, Milan, Italy)

13:00

Lunch

14:00

CANCER PHARMACOLOGY KEYNOTE LECTURE

– Target Selectivity in Drugs and Chemical Probes and the Pharmacological Audit Trail

Paul Workman (The Institute of Cancer Research, London, United Kingdom)

14:30

Clinical Symposium 2

– Gastrointestinal cancer therapeutics

14:30-15:00

Evolutionary landscape of treatment for BRAF mutant colorectal cancer

Andrea Sartore Bianchi (Università di Milano Statale – Ospedale Niguarda, Milan, Italy)

15:00-15:30

Tumor Mutational Burden, microsatellite instability, and actionable alterations in metastatic colorectal cancer

Chiara Cremolini (Università di Pisa – AOUP, Pisa, Italy)

15:30-16:00

Precision oncology in metastatic colorectal cancer

Federica Di Nicolantonio (Università di Torino – IRCCS Candiolo, Turin, Italy)

16:00-16:30

Oesophago-gastric neoplasms and immunotherapy: a new deal for our patients ?

Gérard Milano (Université Côte d’Azur, Nice, France), Enrico Mini (Università di Firenze – AOU Careggi, Florence, Italy)

Chairmen:
Gérard Milano (Université Côte d’Azur, Nice, France),
Enrico Mini (Università di Firenze – AOU Careggi, Florence, Italy)

16:30

Coffee-Break

17:00

PAMM Oral Communications – Session 2

New therapeutics in thoracic malignancies: from bench to bedside

17:00-17:30

Biological underpinnings of pancreatic cancer chemoresistance

Elisa Giovannetti (Amsterdam UMC – Vrije Universiteit Amsterdam,
The Netherlands)

17:30-18:00

Molecular biomarkers for precision medicine in early colorectal cancer

Enrico Mini (Università di Firenze – AOU Careggi, Florence, Italy

18:00-18:30

New players in PDAC-TME: bacteria as biomarkers and potential therapeutic targets

Cindy Neuzillet (Institut Curie, Paris, France)

18:30-19:00

Free communications from abstracts by PAMM members/collaborators :

2 Selected Abstracts

Chairmen:
Andrea Galli (Università di Firenze – AOU Careggi, Florence, Italy),
Jose Padron (University of La Laguna, Tenerife, Spain)

19:00

PAMM BOARD MEETING

19:30

EORTC-PAMM MEETING, WELCOME COCKTAIL

8:30

Basic and Translational Research
Symposium 1 (Pharmacodynamics)

8:30-9:00

Preclinical development of self-assembly anion receptors with metal-dependent kinase inhibition as a novel class of anti-cancer compounds

Roger M. Phillips (University of Huddersfield Queensgate, Huddersfield, UK)

9:00-9:30

Cellular senescence in NSCLC: clinical relevance and preclinical evaluation of senescence-targeting strategies

An Wouters (University of Antwerp, Antwerp, Belgium)

09:30-10:30

Free communications from abstracts by PAMM members/collaborators :

4 Selected Abstracts

Chairmen:
Annette Larsen (Saint-Antoine Research Center, Paris, France),
Paola Perego (Istituto Tumori Milano, Milan, Italy)

10:30

Coffee-Break

11:00

Clinical Symposium 3

– Breast and gynecological cancers therapeutics

11:00-11:30

PARP inhibitors in BRCA1- or BRCA2-Mutated Breast Cancer

Valentina Guarneri (Università di Padova, Padua, Italy)

11:30-12:00

PARP inhibitors in gynaecological cancers and beyond

Judith R.Kroep (Leiden University Medical Center, The Netherlands)

12:00-12:30

Targeting the PI3K pathway in HR-positive breast cancer

Fabrice André (Institut Gustave Roussy, Villejuif and Paris Saclay University, Orsay, France)

Chairmen:
Gianni Amunni (Università di Firenze – ISPRO, Florence, Italy), Andrea Bonetti (Ospedale Mater Salutis, Legnago, Italy)

12:30

Clinical Keynote Lecture

– Car-T CELL and innovative therapies in oncology-Hematology

12:30-13:00

Title TBA

Gabriel Brisou (Paoli Calmettes Institute, Marseille, France)

13:00-13:30

Title TBA

Speaker TBA

13:30

Lunch

14:30

(Bio)technology Techniques Key Lecture 2

NGS in Predictive Molecular Pathology: from tissue to liquid biopsy

Umberto Malapelle (University Federico II of Naples, Naples, Italy)

15:00

Clinical Symposium 4

– Melanoma therapeutics and agnostic therapies

15:00-15:30

Sequential BRAF-MEK inhibition in BRAF V600 Mutation-Positive Advanced Melanoma

Michele Del Vecchio (Istituto Nazionale Tumori, Milan, Italy)

15:30-16:00

New combinations with I-O drugs in melanoma

Michele Maio (Università di Siena, Siena, Italy)

16:00-16:30

Are tumour-agnostic approaches the future for oncology? Successes and hurdles

Giuseppe Curigliano (Università di Milano Statale– Istituto Europeo di Oncologia, Milan, Italy)

Chairmen:
Daniela Massi (Università di Firenze – AOU Careggi, Florence, Italy),
Eric Raymond (Paris Saint-Joseph Hospital Group, Paris, France)

16:30

Coffee-Break

17:00

PAMM Oral Communications – Session 3

New therapeutics in thoracic malignancies: from bench to bedside

17:00-17:30

Background relevance and preclinical/clinical activity of PPT1 inhibitors in patients with advanced cancer

Eric Raymond (Paris Saint-Joseph Hospital Group, Paris, France)

17:30-18:00

Gender-related metabolic differences in melanoma: correlation with an immunosuppressive environment

Elisa Giannoni (Università di Firenze, Florence, Italy)

18:00-18:45

Free communications from abstracts by PAMM members/collaborators :

3 Selected Abstracts

Chairmen:
Giovanni Codacci-Pisanelli (Università di Roma La Sapienza, Rome, Italy), Nicola Pimpinelli (Università di Firenze, Florence, Italy)

18:45

PAMM Business Meeting / General Assembly

20:30

Social Dinner

8:30

Basic and Translational Research
Symposium 2 (Pharmacodynamics)

SECTION 1 : PHARMACOKINETICS OF MONOCLONAL ANTIBODIES

08:30-9:00

Model informed precision dosing of Mabs in oncology : Challenges and opportunities

Dirk Jan Moes (Leiden University Medical Center, Leiden, The Netherlands)

9:00-9:30

TDM of monoclonal antibodies in oncology: hype or hope?

Joseph Ciccolini (Aix-Marseille University, Marseille, France)

SECTION 2 : Pharmacokinetics of protein kinase inhibitors and other anticancer drugs

9:30-10:00

Implementing Therapeutic Drug Monitoring for oral anticancer drugs into clinical routine: The ON-TARGET study

Anna Mc Laughlin (Frei Universität, Berlin, Germany)

10:00-10:30

Pharmacokinetic Considerations for Anticancer Therapy in Children

Georg Hempel (University of Münster, Münster, Germany)

10:30-11:00

Pharmacokinetics of antimetabolites in the modern era

Antonello Di Paolo (Università di Pisa, Pisa, Italy)

11:00-11:15

Free communications from abstracts by PAMM members/collaborators :

1 Selected Abstracts

Chairmen:
Georg Hempel (University of Münster, Münster, Germany),
Marina Ziche (Università di Siena, Siena, Italy)

11:15

Coffee-Break

11:35

Closing lecture

11:35-12:05

Role of EORTC in translational research to support (independent/academic) clinical studies in Europe

Winette Van der Graaf (Netherlands Cancer Institute, Amsterdam)

Chairmen:
Lorenzo Antonuzzo (Università di Firenze AOU Careggi, Florence, Italy)

12:05

PAMM Oral Communications – Session 4

Basic and Translational Research: novel studies from early career investigators

12:05-13:20

Free communications from abstracts by PAMM members/collaborators :

5 Selected Abstracts

Chairmen:
Luigi Messori (Università di Firenze, Florence, Italy), Andrew D. Westwell (Cardiff University, Cardiff, UK)

13:20

Best Oral Communication and Poster Prize and Closure

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Contact Industry & Logistics

Etienne JARRY
+33 (0)6 21 01 73 18
e.jarry@comnco.com

________________
Contact Registrations & Abstracts

Lucille Sarafian
l.sarafian@comnco.com

Zoé Vauthier
z.vauthier@comnco.com

Numéro d’agrément MedTech : EMT27399-PAMM EORTC 2022